Genetic and epigenetic analysis of schizophrenia in blood—a no-brainer?

Table 1 Replication of significant case–control differences

Discovery threshold	Type	Study	Tissue	Probes^a	Genes^b
p < 1 × 10⁻⁷	Discovery	Hannon et al. [4] (Table 1)	Blood	25	16
	Replication	Montano et al. [7] (eTable 4, N = 172)	Blood	0	0
		Aberg et al. [6] (Table 2, N = 65)	Blood	NA	0
		Jaffe et al. [2] (Table S10, N = 2,104)	Brain	0	1
p < 1 × 10⁻⁵	Discovery	Hannon et al. [4] (Table 1)	Blood	1223	949
	Replication	Montano et al. [7] (eTable 4, N = 172)	Blood	2	9
		Aberg et al. [6] (Table 2, N = 65)	Blood	NA	3
		Jaffe et al. [2] (Table S10, N = 2,104)	Brain	6	61

We examined the sites identified as differentially methylated in the Hannon et al. [4] study in the context of previous work across other large blood and brain datasets
^aProbes refer to the exact Illumina 450 k probe by “cg” identifier
^bGenes refer to the nearest gene to each probe or those listed in the tables of the cited papers

ISSN: 1756-994X