Potential contribution of the uterine microbiome in the development of endometrial cancer

Table 4 Significant bacterial operational taxonomic units (OTUs) between benign and endometrial cohorts

Combined q < 0.05	Value	Standard error	Degrees of freedom	t value	p value	q value	Test
OTU 107: Firmicutes; Anaerostipes	3.3	0.725	25	4.6	0.0001	0.014	Presence/absence
OTU 143: Firmicutes; Ruminococcus	3.1	0.738	25	4.2	0.0003	0.019	Presence/absence
OTU 8: Actinobacteria; Atopobium	2.5	0.603	25	4.1	0.0004	0.019	Presence/absence
OTU 3197: Bacteroidetes; Bacteroides	2.5	0.655	25	3.9	0.0007	0.024	Presence/absence
OTU 3213: Bacteroidetes; Bacteroides	1.7	0.499	25	3.5	0.0018	0.043	Presence/absence
OTU 9: Bacteroidetes; Porphyromonas	1.9	0.554	25	3.4	0.0021	0.043	Presence/absence
OTU 138: Bacteroidetes; Bacteroides	1.7	0.517	25	3.4	0.0024	0.043	Presence/absence
OTU 181: Firmicutes; Dialister	2.0	0.585	25	3.4	0.0025	0.043	Presence/absence

Significant bacterial OTUs between benign and endometrial cohorts in the vaginal, cervical, and endometrial microbiome as determined by mixed effect model (FDR q < 0.05). All OTUs shown in the table are enriched (more prevalent) in the endometrial cancer cohort

ISSN: 1756-994X