Gene | Genetic polymorphism | Variant | Genotype frequency (n) [%] | Clearance [l/min] |
---|---|---|---|---|
MDR1 | C1236T | C/C | 31 (34) | 0.77 ± 0.28 |
rs1128503 | C/T | 47 (52) | 0.96 ± 0.37a | |
 | T/T | 21 (24) | 1.11 ± 0.50a | |
G2677T/A | G/G | 29 (32) | 0.77 ± 0.29 | |
(Ala893Ser/Thr) | G/T | 47 (52) | 0.96 ± 0.37b | |
rs2032582 | T/T | 20 (22) | 1.14 ± 0.50b | |
 | G/A | 2 (2) | 0.74 ± 0.03 | |
 | A/A | 0 (-) | - | |
 | T/A | 2 (2) | 0.75 ± 0.10 | |
C3435T | C/C | 19 (21) | 0.83 ± 0.28 | |
rs1045642 | C/T | 62 (68) | 0.97 ± 0.44 | |
 | T/T | 19 (21) | 0.92 ± 0.30 | |
MDR5 | C392T (Thr131Ile) | C/C | 89 (98) | 0.92 ± 0.37 |
rs17143212 | C/T | 11 (12) | 1.07 ± 0.54 | |
 | T/T | 0 (-) | - | |
MRP2 | -C24T | C/C | 73 (80) | 0.92 ± 0.39 |
rs717620 | C/T | 21 (23) | 1.03 ± 0.41 | |
 | T/T | 6 (7) | 0.73 ± 0.33 | |
G1249A (Val417Ile) | G/G | 68 (75) | 0.95 ± 0.41 | |
rs2273697 | G/A | 30 (33) | 0.89 ± 0.37 | |
 | A/A | 2 (2) | 0.97 ± 0.05 | |
ABCG2 | G34A (Val12Met) | G/G | 96 (105) | 0.94 ± 0.40 |
rs2231137 | G/A | 4 (5) | 0.84 ± 0.25 | |
 | A/A | 0 (-) | - | |
C421A (Gln141Lys) | C/C | 75 (82) | 0.94 ± 0.37 | |
rs2231142 | C/A | 25 (28) | 0.91 ± 0.46 | |
 | A/A | 0 (-) | - |