Fig. 4

SNP-modulated gene networks underlying three immunological disease categories. a The top-scoring gene network for the three disease categories: autoinflammatory diseases (orange), mixed diseases (cyan), and autoimmune diseases (red). b Network genes shared by and unique to disease categories. Genes involved in the Jak-STAT signalling pathway are in bold text. c Pathway enrichment analysis of network genes using all pathway ontologies and eliminating redundant pathways. The horizontal dotted line separates pathways common to all three disease categories (top section; e.g. Jak-STAT signalling pathway), those shared by any two categories (middle), and those only enriched in one category (bottom)