Fig. 2

Somatic mutation load by diagnostic category. Box plots comparing overall somatic mutation rates across solid tumors and hematologic conditions detected by NGS. The top and bottom ends of the boxes represent the 25th and 75th percentile values, respectively, and the segment in the middle is the median. The top and bottom extremes of the bars extend to the minimum and maximum values. The box plot depicts the total mutation load excluding four outliers (one solid tumor and three hematologic). See Additional file 4: Figure S1 for inclusive dataset with outliers. The total mutational load (prior to filtering or orthogonal validation) for solid tumors was 4972 variants (mean, 84.3; SD, 43.9; median, 85; range, 15–214) and for hematologic conditions was 1478 variants (mean, 56.85; SD, 34.9; median, 47; range, 14–149)