Fig. 2

Analysis of pathway activity and intrinsic subtypes in a 1119 TCGA breast cancer samples and b 55 ICBP breast cancer cell lines. HER2, IGF1R, and AKT and BAD, EGFR, KRAS (G12V), and RAF1 pathway activities reveal two distinct clusters that were negatively associated. GFRN characterization reveals a dichotomy in TCGA breast cancer patients, high BAD/EGFR/KRAS/RAF1 (growth phenotype; column color label shown in aquamarine) and high HER2/IGF1R/AKT (survival phenotype; column color label shown in coral). Subtypes determined by immunohistochemistry and intrinsic subtyping are shown on the right side row color labels. c K-means clustering of TCGA samples identifies subsets of samples within the survival phenotype that have high HER2 activation and low HER2 activation, and subsets of samples within the growth phenotype that have high BAD activation and low BAD activation (shown in the left side row color labels). d These clusters are also seen in ICBP