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Table 2 Functional properties with significant functional convergence trends

From: Strength of functional signature correlates with effect size in autism

Functional property Spearman’s correlation FDR
Gene essentiality (Georgi et al. [50]) 0.95 0.001
GO:0048699 (generation of neurons) 0.92 0.003
FMRP interactors (Darnell et al. [49]) 0.91 0.003
Brainspan co-expression network 0.90 0.003
SynapseSet (Lips et al. [46]) 0.90 0.003
Haploinsufficiency scores 0.89 0.003
RVIS 0.86 0.007
GSE25219: Overall expression 0.84 0.008
GO:0007409 (axonogenesis) 0.84 0.006
GO:0030182 (neuron differentiation) 0.84 0.006
GO:0048667 (cell morphogenesis involved in neuron differentiation) 0.84 0.006
GO:0061564 (axon development) 0.84 0.006
Chromatin remodeling gene set (Ronan et al. [48]) 0.83 0.006
GSE25219: Fetal expression 0.83 0.006