Fig. 2
From: Parkinson’s disease is associated with DNA methylation levels in human blood and saliva
EWAS results for PD and blood-based DNA methylation analyses without cell composition adjustment. Differential methylation associated with PD status in 508 PEG1 subjects of European ancestry adjusting for age and gender. a Manhattan plot of p values adjusted for age and gender (red line: p value threshold of 10–7). b Distributions of CpGs relative to CpG island and gene regions for all 450,000 CpGs on the microarray and the 82 most significant coffee-associated CpGs listed in Table 1. c Distribution of DNA methylation levels for the top three most significant PD-associated CpGs by PD status (1 = PD)