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Fig. 1 | Genome Medicine

Fig. 1

From: Actionable gene-based classification toward precision medicine in gastric cancer

Fig. 1

The Cancer Genome Atlas molecular subtypes in 207 Japanese gastric cancers (GCs). a The 207 Japanese GCs are classified into four molecular subtypes; Epstein-Barr virus-positive (EBV, red), tumor with microsatellite instability (MSI, blue), tumors with chromosomal instability (CIN, purple), and genomically stable tumors (GS, green). Color tiles indicate pathological and molecular characteristics of of GC. Tumors are ordered by mutation rate and the red dots indicate hypermutated tumors with a mutation rate of more than 18.5 counts/Mb, which was the lowest value in the MSI subtype. b Classification of 207 Japanese GCs into TCGA molecular subtypes. The cutoff value of somatic copy number alterations (SCNAs) is defined as four loci according to the status of TP53 mutation and histological type (Additional file 3: Figure S1). c Distribution of molecular subtypes in 207 Japanese (upper) and TCGA (lower) GCs. d Landscape of frequently observed actionable gene alterations (5% or more) in 207 Japanese GCs classified by TCGA subtype. Alteration color indicates the class of gene alterations

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