| |
Schizophrenia-LIQ (n = 162)a
|
Schizophrenia-average IQ (n = 278)a
|
Analyses
|
|---|
| |
Participants
| |
Participants
|
|---|
|
Gene-set name
|
Total genes (n)
|
CNVs (n)
|
n
|
%
|
CNVs (n)
|
n
|
%
|
p
|
BH-FDR
|
OR
|
|---|
|
GO Nervous system development
|
1874
|
44
|
35
|
18.5
|
29
|
28
|
10.1
|
0.013
|
0.0783
|
1.7
|
|
Union inclusive
|
2874
|
56
|
45
|
23.8
|
43
|
41
|
14.7
|
0.058
|
0.1554
|
1.4
|
|
NMDARb
|
62
|
4
|
4
|
2.1
|
0
|
0
|
0
|
0.078
|
0.1554
|
Inf
|
|
Targets of FMR1, Darnell et al. (2012)
|
840
|
25
|
24
|
12.7
|
21
|
20
|
7.2
|
0.371
|
0.5563
|
1.3
|
|
GO Synaptic
|
622
|
15
|
15
|
8.5
|
11
|
11
|
4.0
|
0.471
|
0.5650
|
1.2
|
|
GO Nervous system transmission
|
716
|
18
|
17
|
9.0
|
10
|
10
|
3.6
|
0.761
|
0.7605
|
1.1
|
-
aAll rare (< 0.1%) autosomal CNVs > 10 kb were included in the analysis; see “Methods” for details. Sample sizes represent those individuals with one or more rare CNVs overlapping at least 1 bp of coding sequence, according to RefSeq annotations, in each group (162/192, or 84.3%, of the schizophrenia-LIQ group; 278/325, or 85.5%, of the schizophrenia-average IQ group)
-
bThe CNVs comprised four pathogenic 16p11.2 duplications in four individuals, for which the contributing gene for this gene-set result was MAPK3
-
LIQ low IQ, GO gene ontology, CNV copy number variation, p statistical result when all rare autosomal CNVs are included; BH-FDR Benjamini–Hochberg false discovery rate, Inf infinity, NMDAR N-methyl-D-aspartate receptor components
