Fig. 4

Pattern frequency of EFC#93 in women from the UKCTOCS. EFC#93 pattern frequency in samples with low (a) or high (b) amounts of DNA in the serum sample. c Performance of EFC#93 serum DNAme marker (cut-off threshold = 0.00008) depending on time to diagnosis and whether or not women subsequently died. Data separated based on DNA amount in the serum sample (95% CI in brackets). P values in (a) and (b) are from a Mann–Whitney U-test and are relative to the control group. Control no cancer developed, BC-D breast cancer which eventually led to death, BC-ND breast cancer which did not lead to death, mo months, yr years