Fig. 2

Drug-related genes with highest probability of having functional variants. a Protein-centered cumulative allele probability (CAP) scores for the 100 drug targets with highest scores (purple) and the contribution of CAP scores as determined from rare variants alone (light purple). Box a1, the top 20 target genes with highest CAP score; box a2, examples of target genes with lower CAP scores. b One-hundred ADME genes with highest CAP scores (blue) and the corresponding CAP score determined from rare variants alone (light blue). Box b1, the top 20 ADME genes with highest CAP scores; box b2, examples of ADME genes with lower CAP scores. Bubble size corresponds to the number of functional variants observed for the respective gene