Fig. 1
From: NSAID use and somatic exomic mutations in Barrett’s esophagus
Differences in 96-trinucleotide somatic base substitutions between NSAID users and non-users. a Difference in median mutation load at each 96 trinucleotide somatic base substitution between NSAID non-users and users. Medians above zero are higher in NSAID non-users. b Box plot for mutation levels in NSAID user (blue) and NSAID non-user (red) at each 96 trinucleotide somatic base substitution. Ten substitutions (indicated by *) had significantly different median mutation level including the following (mean mutation count in user/non-user, p value): C > A at ACA (2.78/4.37, p = 0.03) TCA (3.2/4.59, p = 0.02), and TCT (5.1/7.1, p = 0.04); C > G at TCG (0.22/0.59, p = 0.003); C > T at ACC (2.98/4.17, p = 0.0099); T > A at ATA (0.90/1.58, p = 0.01), ATT (1.63/3.05, p = 0.02) and TTT (1.51/3.2, p = 0.015); T > C at ATA (3.12/4.61, p = 0.008) and GTC (2.0/3.24, p = 0.02), Kruskal–Wallis