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Table 2 Enrichment of AD heritability at variants within SPI1, Spdef, RUNX and no-motif-containing microglia ATAC-seq peaks

From: Genetic risk for Alzheimer’s disease is concentrated in specific macrophage and microglial transcriptional networks

Motif set Enrichment Enrichment P value Corrected P value
SPI1 16.28 1.10 × 10−3 4.39 × 10− 3
Spdef 19.92 9.93 × 10− 3 0.040
No-motif 20.27 0.042 0.168
RUNX 14.09 0.103 0.412
  1. AD heritability was partitioned by transcription factor motif-containing ATAC-seq peaks using LDscore regression [12]. AD heritability was significantly enriched (after correcting for multiple testing) at SPI1 and Spdef transcription factor motif-containing ATAC-seq peaks but not the RUNX or no motif sets
  2. AD Alzheimer’s disease