Fig. 2

H3K79me2 enrichment ChIP-seq data around splice sites of SE and A3SS. a Enrichment plots of H3K79me2 showing the comparison between AS sites and random non-AS sites. Red/green lines show the average H3K79me2 enrichment of AS events and blue lines show the average H3K79me2 enrichment in random non-AS sites, while the pink area highlights the discrepancy in enrichment between AS and non-AS sites. b Percentage of AS sites enriched with different levels of the H3K79me2 mark after comparison with non-AS sites (left) as well as of AS sites with identified H3K79me2 peaks located in alternative sites or junction elements (right). c Peak patterns identified from H3K79me2 peaks in AS events. Each splicing event with a H3K79me2 peak was aligned by its splicing exon start site, and the density of read occupancy around each event (200 bp upstream and 400 bp downstream) was normalized by a z-score method. d Two typical examples of genes with SE events: ZNF512 with a specific SE event in GM12878 cells vs non-SE in primary B cells (left); and MATR3 with a A3SS event in skeletal muscle myoblast cells vs non-A3SS in arm fibroblast cells (right)