Fig. 3

CD94 encoding gene KLRD1 is differentially expressed between asymptomatic nonshedders and symptomatic shedders and correlates with symptom severity at baseline. a Forest plot of effect sizes of baseline KLRD1 expression in discovery cohorts (summary effect size = − 0.54, P = 0.026). The x axes represent standardized mean difference between symptomatic shedders and asymptomatic nonshedders, computed as Hedges’ g, in log2 scale. The size of the blue rectangles is proportional to the SEM difference in the study. Whiskers represent the 95% confidence interval. The yellow diamonds represent overall, combined mean difference for a given gene. Width of the yellow diamonds represents the 95% confidence interval of overall mean difference. b Violin plot of KLRD1 expression at baseline in validation cohort GSE61754 (P = 0.0033). c ROC plot of performance of KLRD1 expression to differentiate asymptomatic nonshedders and symptomatic shedders at baseline (AUC = 0.91, 95% CI 0.75–1.0). d Correlation between baseline KLRD1 expression and logged total symptom score in validation cohort GSE61754 (r = − 0.79, p = 0.00052)