Table 2 Associations from MCH and RDW to cognitive tests as revealed by MR
Median weighted beta [CI] | Median weighted p | IVW beta [CI] | IVW p | Egger beta [CI] | Egger p | |
|---|---|---|---|---|---|---|
MCH trait | ||||||
Reaction | 0.0199 [− 0.0005, 0.0404] | 0.0562 | 0.0091 [− 0.0057, 0.0238] | 0.2320 | 0.0363 [0.01, 0.0627] | 0.0069 |
Reasoning | 0.0568 [0.0195, 0.0941] | 0.0028 | 0.0458 [0.0194, 0.0722] | 0.0012 | 0.0871 [0.0392, 0.1351] | 0.0004 |
Numeric | 0.0977 [0.0364, 0.159] | 0.0018 | 0.0443 [0.0021, 0.0864] | 0.0392 | 0.1327 [0.0544, 0.2111] | 0.0009 |
Visual | − 0.0015 [− 0.0217, 0.0188] | 0.8855 | − 0.0097 [− 0.0235, 0.0041] | 0.1521 | − 0.0182 [− 0.0439, 0.0074] | 0.1640 |
Prospective | 0.0706 [− 0.0149, 0.1562] | 0.1055 | 0.0311 [− 0.0289, 0.0912] | 0.3075 | 0.0506 [− 0.0612, 0.1623] | 0.3752 |
RDW trait | ||||||
Reaction | − 0.0245 [− 0.0788, 0.0298] | 0.3758 | − 0.0135 [− 0.0541, 0.0271] | 0.4528 | − 0.0294 [− 0.1284, 0.0696] | 0.5601 |
Reasoning | − 0.1036 [− 0.2041, − 0.0031] | 0.0432 | − 0.1191 [− 0.1907, − 0.0474] | 0.0025 | − 0.0602 [− 0.235, 0.1146] | 0.4996 |
Numeric | − 0.2121 [− 0.3769, − 0.0472] | 0.0117 | − 0.111 [− 0.2345, 0.0124] | 0.0714 | − 0.3243 [− 0.6247, − 0.0238] | 0.0344 |
Visual | 0.0086 [− 0.0501, 0.0673] | 0.7739 | 0.0428 [− 0.0092, 0.0947] | 0.1307 | 0.0708 [− 0.0598, 0.2015] | 0.2880 |
Prospective | − 0.1024 [− 0.3368, 0.132] | 0.3917 | − 0.1108 [− 0.287, 0.0654] | 0.1858 | 0.0278 [− 0.4019, 0.4575] | 0.8992 |