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Table 2 Associations from MCH and RDW to cognitive tests as revealed by MR

From: Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer’s disease

  Median weighted beta [CI] Median weighted p IVW beta [CI] IVW p Egger beta [CI] Egger p
MCH trait
 Reaction 0.0199 [− 0.0005, 0.0404] 0.0562 0.0091 [− 0.0057, 0.0238] 0.2320 0.0363 [0.01, 0.0627] 0.0069
 Reasoning 0.0568 [0.0195, 0.0941] 0.0028 0.0458 [0.0194, 0.0722] 0.0012 0.0871 [0.0392, 0.1351] 0.0004
 Numeric 0.0977 [0.0364, 0.159] 0.0018 0.0443 [0.0021, 0.0864] 0.0392 0.1327 [0.0544, 0.2111] 0.0009
 Visual − 0.0015 [− 0.0217, 0.0188] 0.8855 − 0.0097 [− 0.0235, 0.0041] 0.1521 − 0.0182 [− 0.0439, 0.0074] 0.1640
 Prospective 0.0706 [− 0.0149, 0.1562] 0.1055 0.0311 [− 0.0289, 0.0912] 0.3075 0.0506 [− 0.0612, 0.1623] 0.3752
RDW trait
 Reaction − 0.0245 [− 0.0788, 0.0298] 0.3758 − 0.0135 [− 0.0541, 0.0271] 0.4528 − 0.0294 [− 0.1284, 0.0696] 0.5601
 Reasoning − 0.1036 [− 0.2041, − 0.0031] 0.0432 − 0.1191 [− 0.1907, − 0.0474] 0.0025 − 0.0602 [− 0.235, 0.1146] 0.4996
 Numeric − 0.2121 [− 0.3769, − 0.0472] 0.0117 − 0.111 [− 0.2345, 0.0124] 0.0714 − 0.3243 [− 0.6247, − 0.0238] 0.0344
 Visual 0.0086 [− 0.0501, 0.0673] 0.7739 0.0428 [− 0.0092, 0.0947] 0.1307 0.0708 [− 0.0598, 0.2015] 0.2880
 Prospective − 0.1024 [− 0.3368, 0.132] 0.3917 − 0.1108 [− 0.287, 0.0654] 0.1858 0.0278 [− 0.4019, 0.4575] 0.8992
  1. Significant results are marked with italic fonts (p < 0.05). Higher and lower confidence intervals for beta scores given in square brackets [CI]