Fig. 4

Changes in proteomic profiles induced by different stress conditions. a Comparison of proteins that were phosphorylated in a breast cancer cell line after gamma-irradiation [49] (blue); in an osteosarcoma cancer cell line after gamma-irradiation [48] (orange) and in a melanoma cancer cell line after neocarzinostatin [50] (red). The number of spliceosomal proteins in a given sector is shown after the slash. b Venn diagram of upregulated proteins in therapy-induced secretomes of ovarian cancer cells (blue circle), glioblastoma cells (orange circle), and ovarian cancer ascites obtained from patients after the course of chemotherapy (red circle) [51, 52]. The number of spliceosomal proteins in a given sector is shown after the slash. c Venn diagram representing the proteins identified in SKOV3 cells before (blue) and after (red) cisplatin treatment. d Results of the enrichment analysis of proteins (from “C”) for which abundance was decreased by more than twofold after chemotherapy. e Results of Fisher’s test of the intersection between differentially secreted proteins (derived from data we reported in [51, 52]) and the hits from siRNA screening (based on the study by Paulsen et al. [53]). f Intersection of the lists of the spliceosomal genes with a decrease in expression (green circle, according to our meta-analyses of microarray data), intron retention in transcripts (blue circle, according to our meta-analyses of RNA-Seq data), upregulated secretion of the corresponding proteins (orange circle, according to our previous proteomic data) and upregulated protein phosphorylation (red circle, according to the analysis of phosphoproteomics data) observed after treatment with chemotherapeutic drugs