|
Patient code
|
Type of isolate
|
Collection interval (days)
|
Context of paired isolate
|
Days of treatment
|
Principal antibiotic
|
mecA
|
Van MIC (μg/ml)
|
Median doubling time
|
Mutations (SNP/indels)
|
Non-silent mutations
|
|---|
|
Small-colony variant and vancomycin MIC increase
|
|
P_03
|
Index
|
–
|
–
|
–
|
–
|
Pos
|
0.75
|
34.5
|
–
|
0
|
|
P_03
|
Paired invasive
|
38
|
Relapse (after treatment)
|
14
|
Van
|
Pos
|
2
|
53.9
|
4 (1/3)
|
4
|
|
P_05
|
Index
|
–
|
–
|
–
|
–
|
Neg
|
1.5
|
38.4
|
–
|
0
|
|
P_05
|
Paired invasive
|
18
|
Relapse (after treatment)
|
12
|
Flx
|
Neg
|
2
|
50.6
|
1 (1/0)
|
1
|
|
P_30
|
Index
|
–
|
–
|
–
|
–
|
Pos
|
1.5
|
42.1
|
–
|
0
|
|
P_30
|
Paired invasive
|
14
|
Persistent
|
14
|
Van
|
Pos
|
2
|
83.5
|
2 (1/1)
|
2
|
|
Vancomycin MIC increase
|
|
P_42
|
Index
|
–
|
–
|
–
|
–
|
Pos
|
2
|
44.7
|
–
|
0
|
|
P_42
|
Paired invasive
|
9
|
Persistent
|
8
|
Van
|
Pos
|
3
|
46.5
|
0 (0/0)
|
0
|
|
P_46
|
Index
|
–
|
–
|
–
|
–
|
Pos
|
2
|
50.6
|
–
|
0
|
|
P_46
|
Paired invasive
|
23
|
Relapse (on treatment)
|
21
|
Van
|
Pos
|
3
|
48.9
|
0 (0/0)
|
0
|
- Van vancomycin, Flx flucloxacillin, MIC minimum inhibitory concentration, SNP single nucleotide polymorphism
