Table 1 Summary of episodes with phenotypic changes
Patient code | Type of isolate | Collection interval (days) | Context of paired isolate | Days of treatment | Principal antibiotic | mecA | Van MIC (μg/ml) | Median doubling time | Mutations (SNP/indels) | Non-silent mutations |
|---|---|---|---|---|---|---|---|---|---|---|
Small-colony variant and vancomycin MIC increase | ||||||||||
 P_03 | Index | – | – | – | – | Pos | 0.75 | 34.5 | – | 0 |
 P_03 | Paired invasive | 38 | Relapse (after treatment) | 14 | Van | Pos | 2 | 53.9 | 4 (1/3) | 4 |
 P_05 | Index | – | – | – | – | Neg | 1.5 | 38.4 | – | 0 |
 P_05 | Paired invasive | 18 | Relapse (after treatment) | 12 | Flx | Neg | 2 | 50.6 | 1 (1/0) | 1 |
 P_30 | Index | – | – | – | – | Pos | 1.5 | 42.1 | – | 0 |
 P_30 | Paired invasive | 14 | Persistent | 14 | Van | Pos | 2 | 83.5 | 2 (1/1) | 2 |
Vancomycin MIC increase | ||||||||||
 P_42 | Index | – | – | – | – | Pos | 2 | 44.7 | – | 0 |
 P_42 | Paired invasive | 9 | Persistent | 8 | Van | Pos | 3 | 46.5 | 0 (0/0) | 0 |
 P_46 | Index | – | – | – | – | Pos | 2 | 50.6 | – | 0 |
 P_46 | Paired invasive | 23 | Relapse (on treatment) | 21 | Van | Pos | 3 | 48.9 | 0 (0/0) | 0 |