Skip to main content

Advertisement

Table 1 Summary of episodes with phenotypic changes

From: Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia

Patient code Type of isolate Collection interval (days) Context of paired isolate Days of treatment Principal antibiotic mecA Van MIC (μg/ml) Median doubling time Mutations (SNP/indels) Non-silent mutations
Small-colony variant and vancomycin MIC increase
 P_03 Index Pos 0.75 34.5 0
 P_03 Paired invasive 38 Relapse (after treatment) 14 Van Pos 2 53.9 4 (1/3) 4
 P_05 Index Neg 1.5 38.4 0
 P_05 Paired invasive 18 Relapse (after treatment) 12 Flx Neg 2 50.6 1 (1/0) 1
 P_30 Index Pos 1.5 42.1 0
 P_30 Paired invasive 14 Persistent 14 Van Pos 2 83.5 2 (1/1) 2
Vancomycin MIC increase
 P_42 Index Pos 2 44.7 0
 P_42 Paired invasive 9 Persistent 8 Van Pos 3 46.5 0 (0/0) 0
 P_46 Index Pos 2 50.6 0
 P_46 Paired invasive 23 Relapse (on treatment) 21 Van Pos 3 48.9 0 (0/0) 0
  1. Van vancomycin, Flx flucloxacillin, MIC minimum inhibitory concentration, SNP single nucleotide polymorphism