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Table 2 Maternal and fetal genome-wide significant association of maternal and neonatal cytokines/chemokines

From: Cross-genetic determination of maternal and neonatal immune mediators during pregnancy

SNP gen chr A1 MAF Beta SE P value Locus SIM Set P value match-gen
rs12327057 Fetal 18p11 C 0.18 − 0.42 0.07 1.4 × 10−8 ADCYAP1 sIL2R-α M 9.4 × 10−4
rs75885714 Fetal 3p24.3 C 0.08 − 0.53 0.05 8.6 × 10−21 PLCL2 CCL17 I 3.8 × 10−6
rs75885714 Fetal 3p24.3 C 0.08 − 0.48 0.05 3.3 × 10−20 PLCL2 CCL19 I 3.8 × 10−6
rs75885714 Fetal 3p24.3 C 0.08 − 0.36 0.04 2.8 × 10−19 PLCL2 CXCL9 I 5.4 × 10−6
rs75885714 Fetal 3p24.3 C 0.08 − 0.23 0.03 8.2 × 10−13 PLCL2 CCL7 I 1.1 × 10−3
rs75885714 Fetal 3p24.3 C 0.08 − 0.24 0.03 5.2 × 10−12 PLCL2 IFN-γ I 6.0 × 10−3
rs75885714 Fetal 3p24.3 C 0.08 − 0.27 0.04 2.1 × 10−12 PLCL2 IL-2 I 1.5 × 10−3
rs75885714 Fetal 3p24.3 C 0.08 − 0.26 0.04 1.7 × 10−11 PLCL2 IL-6 I 9.7 × 10−4
rs75885714 Fetal 3p24.3 C 0.08 − 0.20 0.03 1.8 × 10−11 PLCL2 IL-10 I 3.8 × 10−4
rs75885714 Fetal 3p24.3 C 0.08 − 0.22 0.03 3.5 × 10−10 PLCL2 IL-1β I 1.4 × 10−3
rs75885714 Fetal 3p24.3 C 0.08 − 0.17 0.03 9.3 × 10−10 PLCL2 CXCL13 I 1.3 × 10−4
rs75885714 Fetal 3p24.3 C 0.08 − 0.16 0.03 2.0 × 10−8 PLCL2 CX3CL1 I 9.8 × 10−4
rs1003645 Fetal 17q12 C 0.28 − 0.63 0.02 2.5 × 10−100 CCL23 CCL23 I 3.4 × 10−24
rs854625 Fetal 17q12 A 0.12 0.47 0.04 4.6 × 10−25 CCL15 CCL15 I 1.1 × 10−6
rs3921 Fetal 4q21.1 C 0.29 0.24 0.03 2.0 × 10−14 CXCL9/10/11 CXCL11 I 1.2 × 10−3
rs16850073 Fetal 4q13.3 T 0.32 0.10 0.02 6.4 × 10−9 CXCL6 CXCL6 I 6.8 × 10−6
rs73359750 Fetal 7q11.23 T 0.08 0.86 0.16 4.9 × 10−8 CCL24 CCL24 I NS
rs41272321 Fetal 3q22.1 G 0.13 − 0.20 0.03 2.8 × 10−10 ACKR4 CCL21 I 3.3 × 10−4
rs2228467 Fetal 3p22.1 C 0.04 0.29 0.05 2.8 × 10−8 ACKR2 CXCL9 I 0.01
rs2228467 Fetal 3p22.1 C 0.04 0.42 0.07 4.4 × 10−9 ACKR2 CCL19 I 0.03
rs2228467 Fetal 3p22.1 C 0.04 0.48 0.07 1.8 × 10−10 ACKR2 CCL17 I 0.02
rs74331971 Fetal 8p23.3 A 0.03 − 0.40 0.07 1.9 × 10−9 FBXO25/TDRP IL-4 I 0.03
rs4303899 Fetal 3q13.32 G 0.12 − 0.09 0.02 1.7 × 10−8 lincRNA CXCL12 I NS
rs115463265 Maternal 3p24.2 T 0.02 − 1.50 0.24 1.6 × 10−9 THRB/RARB CCL11 M NS
rs12778662 Maternal 10p15.1 T 0.07 0.65 0.11 3.7 × 10−9 IL2R sIL2R-α M 0.04
rs1562064 Maternal 4q31.21 G 0.32 − 0.74 0.13 2.1 × 10−8 near SMAD1 IL1-α M 1.5 × 10−3
rs34642455 Maternal 7q22.1 C 0.13 − 2.17 0.38 3.1 × 10−8 CYP3A4 CXCL5 I 3.6 × 10−3
rs72751339 Maternal 15q26.2 T 0.02 − 1.52 0.25 1.3 × 10−8 MCTP2 CCL24 I 1.7 × 10−3
rs17159338 Maternal 5q21.3 C 0.03 − 0.36 0.06 1.2 × 10−9 near EFNA5 IL-16 I NS
  1. gen genetics, chr chromosomal region, A1 tested allele, MAF minor allele frequency, Set dataset, M mothers, I infants and NS not significant