Cross-genetic determination of maternal and neonatal immune mediators during pregnancy

Table 3 Maternal-specific allele-based proportion of genetic variance and fetal-specific allele-based proportion of genetic variance for maternal and neonatal chemokines and cytokines under a no dosage compensation model

SIM	Dataset	Maternal-only non transmitted allele			Fetal-only non inherited allele
SIM	Dataset	V _(g) /Vp	SE	P value	V _(g) /Vp	SE	P value
Chemokines
CXCL10	Mothers	0.81	0.19	7.1 × 10⁻³	0.81	0.20	0.01
CCL1	Infants	0.63	0.31	0.09	0.75	0.26	0.04
CCL3	Infants	0.47	0.40	NS	0.41	0.44	NS
CCL17	Infants	0.75	0.25	0.05	0.81	0.22	0.02
CCL19	Infants	0.80	0.23	0.03	0.83	0.21	0.01
CCL22	Infants	0.95	0.16	2.8 × 10⁻³	0.83	0.22	0.02
CCL25	Infants	0.48	0.37	NS	0.39	0.44	NS
CXCL5	Infants	0.87	0.20	0.025	0.45	0.41	NS
Cytokines
IL-4	Infants	0.49	0.40	NS	0.00	0.73	NS
IL-7	Mothers	0.79	0.21	0.0163	0.99^#	0.17	< 0.01

ISSN: 1756-994X