Fig. 2

Rearrangement probabilities and population frequencies of TCRs specific for different antigens. a Estimated rearrangement probabilities for TCRs specific for 33 different HLA class I-restricted epitopes. Only epitopes associated with at least 30 different TCR amino acid sequences were selected from VDJdb (n = 5623 TCRs). The distribution of theoretical rearrangement probabilities is shown using violin plots; red dots indicate the median rearrangement probabilities. The variance of specific TCR frequencies across different epitopes is highly significant (P < 10⁻²⁷, ANOVA for log probabilities). b As in a, but the TCR sequences are grouped by epitope origin. The difference in rearrangement probabilities among epitopes grouped by origin is also highly significant (P < 10⁻¹¹, ANOVA for log probabilities). c Fractions of clonotypes specific for different epitopes showing population frequencies of 5–9%, 10–14%, 15–19%, or 20%+ in 786 immune repertoire samples from Emerson et al. d As in c, but grouped by epitope origin