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Fig. 1 | Genome Medicine

Fig. 1

From: Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Fig. 1

Coreceptor and costimulation blockade facilitates survival and maturation of hESC-derived pancreatic islets in NOD.Foxp3hCD2 mice. a A schematic diagram showing the simplified stepwise differentiation protocol to generate human pancreatic islets from hESCs. b, c Immunostaining for the lineage-specific markers of human pancreatic islets b before and c after 1-month transplantation of hESC-islets in NOD.Foxp3hCD2 mice (n = 6) following treatment with coreceptor and costimulation blockade. Scale bars in b: 50 μm and in c: 20 μm

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