Table 2 Common genes in autoimmunity identified as targets for drugs
Annotated gene | Genes in direct PPI | Targeted drugs | Action | Indication | Potential new clinical application |
|---|---|---|---|---|---|
Indicated for CeD, RA, T1D, and/or SSc | |||||
CD28 | CD80 | Abatacept | Antagonist | RA | CeD |
IL12A/TYK2 | IL6R | Tocilizumab | Antibody | RA | CeD, SSc, T1D |
Sarilumab | Antagonist, antibody | RA | |||
IL1R1 | Anakinra | Antagonist | RA | ||
PTPN2/STAT4 | JAK1/JAK2/JAK3 | Tofacitinib | Inhibitor | RA | CeD, SSc, T1D |
TNFAIP3 | TNF | Etanercept | Antibody | RA | CeD, SSc, T1D |
Adalimumab | Antibody | RA | |||
Infliximab | Inhibitor | RA | |||
Other indications | |||||
CD28 | CD2 | Alefacept | Inhibitor | Psoriasis | CeD, RA |
CD28/IL12A/IL2RA/STAT4/TYK2 | IFNG | Olsalazine | NA | Inflammatory bowel disease | CeD, RA, SSc, T1D |
CCL21 | C5 | Eculizumab | Antibody | Paroxysmal nocturnal haemoglobinuria | CeD, RA |
CXCR4 | Plerixafor | Antagonist | Cancer | ||
CCL21/IL12A/TYK2 | CCR5 | Maraviroc | Antagonist | HIV | CeD, RA, SSc, T1D |
CTLA4 | Ipilimumab | NA | Cancer | RA, T1D | |
FASLG/IL12A/IL2RA/IRF5/STAT4/TYK2 | IL12B | Ustekinumab | Antibody | Psoriasis and psoriatic arthritis | CeD, RA, SSc, T1D |
IL12A/IL2RA/TYK2 | IL3RA | Sargramostim | Agonist | Cancer | CeD, RA, SSc, T1D |
IL12A/IRF5/TYK2 | IL1B | Canakinumab | Binder | Systemic juvenile idiopathic arthritis | CeD, RA, SSc, T1D |
IL12A/TYK2 | IFNGR1 | Interferon gamma-1b | Chronic granulomatous disease | CeD, RA, SSc, T1D | |
IL2RA | Aldesleukin | Agonist, Modulator | Cancer | CeD, RA, SSc, T1D | |
Basiliximab | Antibody | Kidney transplant rejection | |||
Daclizumab | Antibody | Multiple sclerosis | |||
Denileukin diftitox | Binder | Cancer | |||
IL2RA/IRF5/TYK2 | IL6 | Siltuximab | Antagonist antibody | Castleman’s disease | CeD, RA, SSc, T1D |
IL2RA/STAT4/TYK2 | IL23A | Guselkumab | Blocker | Psoriasis | CeD, RA, SSc, T1D |
ITGA4 | Natalizumab | Antibody | Multiple sclerosis | CeD, SSc | |
Vedolizumab | Antibody | Crohn disease and ulcerative colitis | |||