Fig. 1
From: Loss of BAP1 as a candidate predictive biomarker for immunotherapy of mesothelioma
Comparison of immune infiltration scores for activated dendritic cells (left) and PD-L1 expression levels (right) as a function of BAP1 inactivation status in 74 PlM samples from the TCGA cohort [6]. BAP1 status was assessed as described by Hmeljak et al. [6]. The immune scores were computed using the single-sample gene-set-enrichment analysis (ssGSEA) and the immune infiltrate gene signatures from Bindea et al. [10]. Reported p values are based on a two-sided Wilcoxon rank-sum test. BAP1 ubiquitin carboxyl-terminal hydrolase BAP1, PD-L1 programmed cell death 1 ligand 1, PlM pleural mesothelioma