Fig. 2

Decomposing the expression landscape of lymphomas into spot modules of co-expressed genes. a The overview map collects all differentially expressed modules observed in the subtype-specific portraits into one map. The sample class(es) expressing the respective spot module(s) is/are assigned in the figure, thus segmenting the landscape into regions typically upregulated in certain lymphoma subtypes. Spot modules were labeled by capital letters A–M. Dark red/blue areas refer to over-/under-expression, respectively. b Probabilities of concerted module activation show that diverse sets of spot modules, e.g. A, B and D, are frequently upregulated in concert. Notably, spot A often appears also together with spot I, which is characteristic for double-hit lymphomas (see also Additional file 1: Figure S4). The color of the module labels represents the corresponding lymphoma subtype. c Spot-class association histograms depict the fraction of samples showing a certain spot in each class. It indicates, for example, that spots A, B and D are prevalent in the BL portraits in agreement with the assignments shown in panel a. d The spot number histograms show the fraction of samples with one, two etc. over-expression spots in each class. It reveals, that in most BL samples three spots can be observed, while DLBCL and FL/DLBCL show a broader variability of spots. Only the five most abundant lymphoma strata (i)–(v) are shown