Fig. 4From: Standard operating procedure for curation and clinical interpretation of variants in cancerDiagram of knowledge model for CIViC Assertions. Assertions summarize a collection of Evidence Items to make a definitive clinical statement about the Variant in a specific Disease context which incorporates all known data within the knowledgebase. Assertions features (green box) build on the Evidence Item knowledge model to bring together clinical guidelines, public resources, and regulatory approvals relevant to a final variant interpretation. Assertions can be associated with any number of Evidence Items. Like Evidence Items, Assertion Type, Direction, and Clinical Significance can be used to create a specific meaning for the AssertionBack to article page