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Table 1 Demographics of exome-sequenced adult BioMe Biobank participants and of individuals harboring expected pathogenic variants in BRCA1/2

From: Exome sequencing reveals a high prevalence of BRCA1 and BRCA2 founder variants in a diverse population-based biobank

 Sequenced BioMe participants (N = 30,223)BRCA1/2 variant negative (N = 27,060)*BRCA1/2 variant positive (N = 218)
Age, median (IQR)59 (45–70)59 (46–70)58 (43–70)
Female, N (%)17,914 (59.3)15,986 (59.1)137 (62.8)
Self-reported ancestry, N (%)
 African American/African6878 (22.8)5877 (28.3)33 (15.1)
 East/Southeast Asian757 (2.5)659 (3.2)6 (2.8)
 European7772 (25.7)7265 (35.0)121 (55.8)
 Hispanic/Latino10,460 (34.6)9360 (45.1)34 (15.6)
 Native American52 (0.2)47 (0.2)0 (0)
 South Asian605 (2.0)543 (2.6)0 (0)
 Other2343 (7.8)2111 (10.2)13 (6.0)
 Multiple selected1125 (3.7)1006 (4.9)10 (4.6)
 Not available231 (0.8)192 (0.9)1 (0.5)
  1. *Variant-negative participants are defined as not having any variants that were pathogenic, uncertain/conflicting, or unclassified in ClinVar