Table 1 The closest known CHD-causing gene to the 23 candidate genes calculated by HGC
From: De novo variants in exomes of congenital heart disease patients identify risk genes and pathways
Candidate | Known | Distance | p value | Route | Degrees of separation |
|---|---|---|---|---|---|
APBB1 | MGRN1 | 1.77 | 0.00078 | MGRN1[1.77]APBB1 | 1 |
BOD1L1 | SOX2 | 3.27 | 0.01344 | SOX2[3.26]BOD1L1 | 1 |
BRD4 | HEXIM1 | 1.25 | 0.00012 | HEXIM1[1.25]BRD4 | 1 |
CABIN1 | PPP3CB | 1.11 | 0.00239 | PPP3CB[1.11]CABIN1 | 1 |
CAD | ACACB | 1.04 | 0.00012 | ACACB[1.04]CAD | 1 |
CDK13 | CDC73 | 1.48 | 0.00227 | CDC73[1.48]CDK13 | 1 |
CHD4 | ZEB2 | 1.25 | 6.00E-05 | ZEB2[1.25]CHD4 | 1 |
CTR9 | CDC73 | 1.08 | 0.00024 | CDC73[1.07]CTR9 | 1 |
GANAB | CALR | 1.11 | 0.0003 | CALR[1.11]GANAB | 1 |
HSP90AA1 | AIP | 1.11 | 6.00E-05 | AIP[1.11]HSP90AA1 | 1 |
IQGAP1 | WHSC1 | 1.25 | 0.0003 | WHSC1[1.25]IQGAP1 | 1 |
KDM5A | RBPJ | 1.25 | 0.00329 | RBPJ[1.25]KDM5A | 1 |
LAMB1 | DAG1 | 1.11 | 0.00054 | DAG1[1.11]LAMB1 | 1 |
LAMC1 | DAG1 | 1.11 | 0.00167 | DAG1[1.11]LAMC1 | 1 |
MINK1 | KIFAP3 | 1.75 | 0.0009 | KIFAP3[1.74]MINK1 | 1 |
NAA15 | NEK1 | 6.01 | 0.01703 | NEK1[1.25]XRCC5[1.75]NAA15 | 2 |
PHIP | CSNK2A1 | 3.28 | 0.01285 | CSNK2A1[3.27]PHIP | 1 |
POGZ | HDAC7 | 4.08 | 0.00759 | HDAC7[4.08]POGZ | 1 |
PYGL | GBE1 | 4.44 | 0.00191 | GBE1[1.11]GYG2[1.11]PYGL | 2 |
RACGAP1 | DSP | 4.72 | 0.00269 | DSP[1.25]PKP4[1.11]RACGAP1 | 2 |
ROCK2 | MYH10 | 1.11 | 0.00036 | MYH10[1.11]ROCK2 | 1 |
TJP2 | RAPGEF2 | 1.25 | 0.00018 | RAPGEF2[1.25]TJP2 | 1 |
USP4 | HUWE1 | 1.77 | 0.00149 | HUWE1[1.77]USP4 | 1 |