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Table 1 The closest known CHD-causing gene to the 23 candidate genes calculated by HGC

From: De novo variants in exomes of congenital heart disease patients identify risk genes and pathways

CandidateKnownDistancep valueRouteDegrees of separation
APBB1MGRN11.770.00078MGRN1[1.77]APBB11
BOD1L1SOX23.270.01344SOX2[3.26]BOD1L11
BRD4HEXIM11.250.00012HEXIM1[1.25]BRD41
CABIN1PPP3CB1.110.00239PPP3CB[1.11]CABIN11
CADACACB1.040.00012ACACB[1.04]CAD1
CDK13CDC731.480.00227CDC73[1.48]CDK131
CHD4ZEB21.256.00E-05ZEB2[1.25]CHD41
CTR9CDC731.080.00024CDC73[1.07]CTR91
GANABCALR1.110.0003CALR[1.11]GANAB1
HSP90AA1AIP1.116.00E-05AIP[1.11]HSP90AA11
IQGAP1WHSC11.250.0003WHSC1[1.25]IQGAP11
KDM5ARBPJ1.250.00329RBPJ[1.25]KDM5A1
LAMB1DAG11.110.00054DAG1[1.11]LAMB11
LAMC1DAG11.110.00167DAG1[1.11]LAMC11
MINK1KIFAP31.750.0009KIFAP3[1.74]MINK11
NAA15NEK16.010.01703NEK1[1.25]XRCC5[1.75]NAA152
PHIPCSNK2A13.280.01285CSNK2A1[3.27]PHIP1
POGZHDAC74.080.00759HDAC7[4.08]POGZ1
PYGLGBE14.440.00191GBE1[1.11]GYG2[1.11]PYGL2
RACGAP1DSP4.720.00269DSP[1.25]PKP4[1.11]RACGAP12
ROCK2MYH101.110.00036MYH10[1.11]ROCK21
TJP2RAPGEF21.250.00018RAPGEF2[1.25]TJP21
USP4HUWE11.770.00149HUWE1[1.77]USP41