Fig. 1

Per-patient distribution of mutation and neoepitope burdens across 7 cancer types. a The number of somatic DNA variants per patient (scaled for sequence coverage) are shown along the y-axis, with each dot representing an individual cancer patient (cancer types shown along the x-axis). Note that MMR-deficient cancers here represent a cohort of three different cancer types including colon, endometrial, and thyroid with evidence of mismatch repair deficiency as determined by polymerase chain reaction or immunohistochemistry [9]. Red colored dots correspond to patients with microsatellite instability as determined by mSINGS (see “Methods”). b The number of putative neoepitopes per patient are shown along the y-axis, with each dot representing an individual cancer patient (cancer types shown along the x-axis). Abbreviations as follows: MMR = mismatch repair