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Table 1 Immunotherapy (αPD1 and αCTLA4) response probability based on logistic regression models of tumor mutational burden (TMB), neoepitope burden (Neoepitopes), and combined tumor DNA- and RNA- variant burden (TVB) for melanoma, non-small cell lung cancer (NSCLC), and renal cell carcinoma (RCC). P values are reported on a per-model basis without correction for multiple comparisons per cancer type

From: Burden of tumor mutations, neoepitopes, and other variants are weak predictors of cancer immunotherapy response and overall survival

Cancer type & Metric

aPD1

aCTLA4

p-value

N

Response Probability (25th %ile)

Response Probability (75th %ile)

N

Response Probability (25th %ile)

Response Probability (75th %ile)

Melanoma

 TMB

50

0.456

0.507

195

0.298

0.342

0.267

 Neoepitopes

50

0.470

0.507

195

0.302

0.334

0.378

 TVB

27

0.367

0.490

61

0.307

0.424

0.079

NSCLC

 TMB

33

0.291

0.578

   

0.034

 Neoepitopes

33

0.345

0.583

   

0.053

RCC

 TMB

50

0.656

0.666

   

0.894

 Neoepitopes

50

0.662

0.66

   

0.973

 TVB

17

0.641

0.538

   

0.600