Translating insights from neuropsychiatric genetics and genomics for precision psychiatry

Table 2 Summary of genetic findings for neuropsychiatric disorders

Disorder	GWAS						Exome sequencing					CNVs
Disorder	Cases	Control	GWAS loci	Population prevalence (k)	Liability-based SNP heritability (SE)	Reference	Cases	Control	Trios/quads	Ngenes	Reference	Cases	Control	Trios/quads	Loci	Reference
SCZ	40,675	64,643	145	0.007	0.23 (0.0063)	[4]	4264	9343	1077	1	[5]	21,094	20,227		8	[6]
BP	20,352	31,358	17	0.01	0.18 (0.011)	[7]	1201	5233		0	[8]	9129	63,068		1	[9]
ADHD	20,183	35,191	12	0.05	0.22 (0.014)	[10]	4263	5233		0	[8]	896	2455		1	[11]
AN	3495	10,982	1	0.01	0.20 (0.021)	[12]
ASD	18,381	27,969	5	0.012	0.12 (0.010)	[13]	5556	8809	6430	102	[14]			5574	10	[15]
MDD	135,458	344,901	44	0.15	0.087 (0.004)	[16]						23,979	383,095		3	[17]
OCD	2688	7037	0	0.025	0.28 (0.04)	[18]						1613	1789		1	[19]
TS	4819	9488	0	0.008	0.21 (0.024)	[20]			802	1	[21]	2434	4093		2	[22]
DD	6987	9270	0	0.01	0.077 (0.021)	[23]			7580	94	[24]	29,085	19,584		70	[25]

Common allele loci from genome-wide association studies (GWAS) are reported from the largest SNP-based studies. Individual genes associated with rare coding variants are reported from exome-sequencing studies with > 3000 cases and controls or > 500 proband-parent trios. Loci enriched for rare copy number variants (CNVs) are reported from studies with > 3000 cases and controls. ADHD attention-deficit hyperactivity disorder, AN anorexia nervosa, ASD autism spectrum disorder, BD bipolar disorder, MDD major depressive disorder, OCD obsessive-compulsive disorder, TS Tourette syndrome, SZ schizophrenia, DD developmental disorders, SE standard error

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