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Table 2 Summary of genetic findings for neuropsychiatric disorders

From: Translating insights from neuropsychiatric genetics and genomics for precision psychiatry

Disorder GWAS Exome sequencing CNVs
Cases Control GWAS loci Population prevalence (k) Liability-based SNP heritability (SE) Reference Cases Control Trios/quads Ngenes Reference Cases Control Trios/quads Loci Reference
SCZ 40,675 64,643 145 0.007 0.23 (0.0063) [4] 4264 9343 1077 1 [5] 21,094 20,227   8 [6]
BP 20,352 31,358 17 0.01 0.18 (0.011) [7] 1201 5233   0 [8] 9129 63,068   1 [9]
ADHD 20,183 35,191 12 0.05 0.22 (0.014) [10] 4263 5233   0 [8] 896 2455   1 [11]
AN 3495 10,982 1 0.01 0.20 (0.021) [12]           
ASD 18,381 27,969 5 0.012 0.12 (0.010) [13] 5556 8809 6430 102 [14]    5574 10 [15]
MDD 135,458 344,901 44 0.15 0.087 (0.004) [16]       23,979 383,095   3 [17]
OCD 2688 7037 0 0.025 0.28 (0.04) [18]       1613 1789   1 [19]
TS 4819 9488 0 0.008 0.21 (0.024) [20]    802 1 [21] 2434 4093   2 [22]
DD 6987 9270 0 0.01 0.077 (0.021) [23]    7580 94 [24] 29,085 19,584   70 [25]
  1. Common allele loci from genome-wide association studies (GWAS) are reported from the largest SNP-based studies. Individual genes associated with rare coding variants are reported from exome-sequencing studies with > 3000 cases and controls or > 500 proband-parent trios. Loci enriched for rare copy number variants (CNVs) are reported from studies with > 3000 cases and controls. ADHD attention-deficit hyperactivity disorder, AN anorexia nervosa, ASD autism spectrum disorder, BD bipolar disorder, MDD major depressive disorder, OCD obsessive-compulsive disorder, TS Tourette syndrome, SZ schizophrenia, DD developmental disorders, SE standard error