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Fig. 2 | Genome Medicine

Fig. 2

From: Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma

Fig. 2

Asthma GWAS genes are over-represented among DEGs in response to IL-13 and/or IL-17A and among DEGs in cases compared to controls. In all panels, blue refers to IL-13 treated cells, red to IL-17A treated cells, and purple to IL-13+IL-17A treated cells. a DEGs following exposure to IL-13 and/or IL-17A were enriched for GWAS catalog genes near variants associated with asthma (N = 586) compared to all non-DEGs on the array. The numbers of DEGs for each exposure are shown on the X-axis, and the proportions of GWAS genes are shown on the Y-axis. b The 8 most significant DEGs are listed. The Venn diagram illustrates the total numbers and overlaps of DEGs that are also near SNPs highlighted in asthma GWASs

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Genome Medicine

ISSN: 1756-994X

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