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Table 1 List of 44 APOBEC-associated hotspot mutations and their frequencies in bladder cancer (n = 602)

From: Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer

Gene mutation N. of mutated samples
FGFR3 S249C 51
PIK3CA E545K 47
ERBB2 S310F 27
PIK3CA E542K 25
RXRA S427F 19
TP53 E285K 17
TP53 R280T 15
KDM6A Q555* 11
TBC1D12 *1* 11
C3orf70 S6L 10
RHOB E172K 9
AHR Q383H 8
LPAR6 F316F 8
TP53 Q331* 8
TP53 E271K 8
RARS2 R6C 7
SF3B1 E902K 7
TP53 R280K 7
ERBB3 E332K 6
MROH2B E1109K 6
PIK3CA E545Q 6
PPCS S113L 6
STAG2 Q593* 6
ACSS3 S290L 5
CELSR3 E356K 5
KCNF1 E158K 5
PDE3A L275L 5
PIK3CA E726K 5
PLXNA2 E1480K 5
RHOB E47K 5
TFPI2 R222C 5
TP53 K132N 5
CAMK2G I132I 4
CELSR1 E1382K 4
EP300 Q1082* 4
ERBB4 E317K 4
FAM90A1 L251L 4
FURIN R693W 4
KDM6A S1061* 4
PBX2 E70K 4
RB1 Q217* 4
RREB1 Q392* 4
TP53 Q192* 4
TTC23L Q263Q 4
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