Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes

Table 1 ASD DMR genes replicate in males and females in independent sample sets

Gene set 1	Genes	Gene set 2	Genes	Overlap	% Overlap	Odds ratio	p value
Discovery	949	Replication	5429	537	56.6	5.13	1.2E−126
Males (n = 74)	949	Males (n = 38)	5429	537	56.6	5.13	1.2E−126
Discovery	2912	Replication	9496	1762	60.5	2.86	3.6E−153
Females (n = 32)	2912	Females (n = 8)	9496	1762	60.5	2.86	3.6E−153
Replicated	537	Replicated	1762	162	30.2	6.20	4.0E−60
Males (All chrs)	537	Females (All chrs)	1762	162	30.2	6.20	4.0E−60
Replicated	55	Replicated	173	21	38.2	3.48	4.6E−5
Males (chrX)	55	Females (chrX)	173	21	38.2	3.48	4.6E−5

ISSN: 1756-994X