Fig. 6

OSE-like tumors show an immunomodulatory phenotype. a Dotplot showing the number of CD8+ cells (top panels) and CD4+ cells (bottom panels) in stromal and intratumoral regions. Mann-Whitney U test was used to derive statistical significance (*p < 0.05, **p < 0.01, ns = non-significant). b Immunohistochemistry staining for CD8 and CD4 in FI-like and OSE-like tumors. Representative pictures are shown. Red arrows: stromal positive cells. Black arrows: intratumoral positive cells. Scale bar = 100 μm. c Kaplan-Meier overall survival curves for FI-like and OSE-like affected patients, subdivided in CD8 high and low. The dashed line is set at 3-year survival. Log rank test results for significance are shown in the bottom table. d Heatmap of the level of protein expression of cytokines/chemokines segregating FI-like (purple) and OSE-like (orange) tumors. Distance = Euclidean