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Table 1 Study characteristics of the CENTRAL subgroup selected for genome wide DNA methylation analysis

From: DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

Trait CENTRAL all (N = 120) P value Low carb (N = 30) Low carb + PA (N = 30) Low fat (N = 30) Low fat + PA (N = 30)
Gender (N; female/male) 10/110   4/26 0/30 5/25 1/29
Age (years)       
 T0 49 ± 9.3   47 ± 7.5 50 ± 9.8 50 ± 10.2 48 ± 9.5
Weight (kg)       
 T0 90.32 ± 11.5   89.98 ± 14.5 90.58 ± 11.6 87.64 ± 10.4 93.07 ± 8.5
 T18 86.66 ± 11.2   88.50 ± 14.2 85.44 ± 10.8 83.61 ± 9.5 89.11 ± 9.1
 Δ(T18-T0) − 3.65 ± 5.2 < 1 × 10−11 − 1.48 ± 3.3* − 5.14 ± 5.6*** − 4.04 ± 6.6** − 3.96 ± 4.2***
BMI (kg/m2)       
 T0 30.17 ± 3.3   30.09 ± 4.6 30.13 ± 2.4 30.38 ± 3.3 30.08 ± 2.5
 T18 28.97 ± 3.4   29.60 ± 4.4 28.45 ± 2.5 29.02 ± 3.4 28.80 ± 2.8
 Δ(T18-T0) − 1.20 ± 1.7 < 1 × 10−11 − 0.49 ± 1.1* − 1.68 ± 1.8*** − 1.36 ± 2.1** − 1.27 ± 1.4***
Waist circumference (cm)       
 T0 106.70 ± 8.1   106.56 ± 11.3 108.29 ± 6.7 104.63 ± 7.3 107.56 ± 5.9
 T18 101.98 ± 8.4   103.49 ± 12.0 100.96 ± 7.0 100.50 ± 6.6 102.92 ± 6.7
 Δ(T18-T0) − 4.81 ± 5.6 < 1 × 10−14 − 3.07 ± 4.0*** − 7.3 ± 6.2*** − 3.64 ± 6.3** − 5.29 ± 5.1***
HbA1c (%)       
 T0 5.59 ± 0.5   5.66 ± 0.6 5.61 ± 0.4 5.60 ± 0.5 5.49 ± 0.4
 T18 5.51 ± 0.5   5.62 ± 0.8 5.47 ± 0.4 5.55 ± 0.5 5.39 ± 0.3
 Δ(T18-T0) − 0.08 ± 0.3 0.005 − 0.04 ± 0.5 − 0.14 ± 0.2*** − 0.06 ± 0.3 − 0.10 ± 0.2**
Insulin (μU/mL)       
 T0 18.02 ± 11.3   21.06 ± 15.2 16.85 ± 8.15 17.55 ± 12.1 16.56 ± 8.0
 T18 14.18 ± 7.3   16.66 ± 8.6 13.98 ± 8.1 12.67 ± 6.8 13.50 ± 4.7
 Δ(T18-T0) − 3.91 ± 7.8 < 1 × 10−6 − 4.54 ± 10.5* − 3.40 ± 6.24** − 4.66 ± 7.8** − 3.07 ± 6.3*
Visceral adipose tissue area (cm2)       
 T0 176.19 ± 61.3   162.00 ± 63.6 196.5 ± 63.5 160.60 ± 60.8 185.70 ± 51.3
 T18 128.12 ± 49.8   126.41 ± 47.9 131.33 ± 56.2 121.03 ± 54.3 133.70 ± 41.0
 Δ(T18-T0) − 48.19 ± 36.2 < 1 × 10− 27 −35.54 ± 32.7*** − 65.21 ± 38.1*** − 39.73 ± 28.4*** − 52.00 ± 38.6***
Deep subcutaneous adipose tissue area (cm2)       
 T0 210.89 ± 70.0   217.50 ± 79.6 210.40 ± 64.8 201.30 ± 66.9 214.30 ± 70.2
 T18 144.71 ± 48.7   152.99 ± 60.2 139.50 ± 41.7 143.39 ± 41.6 142.96 ± 50.5
 Δ(T18-T0) − 66.66 ± 42.1 < 1 × 10−33 − 64.55 ± 38.6*** − 70.95 ± 45.9*** − 59.59 ± 48.1*** − 71.31 ± 35.9***
Superficial subcutaneous adipose tissue area (cm2)       
 T0 134.89 ± 56.5   146.20 ± 74.7 125.20 ± 47.6 135.90 ± 59.9 132.20 ± 37.9
 T18 106.76 ± 44.1   121.37 ± 55.8 94.4 ± 31.8 111.29 ± 50.3 99.99 ± 29.53
 Δ(T18-T0) − 28.02 ± 23.9 < 1 × 10−23 − 24.85 ± 30.1*** − 30.85 ± 24.5*** − 24.01 ± 22.8*** − 32.23 ± 16.5***
  1. Metabolic traits are shown as mean ± SD values prior intervention (T0), post-intervention (T18), and the intervention specific changes (Δ(T18-T0)). P values obtained from paired t-statistics between T0 and T18 are shown for the entire cohort and indicated as: *P < 0.05; **P < 0.01; ***P < 0.001, for the intervention specific changes