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Table 1 Study characteristics of the CENTRAL subgroup selected for genome wide DNA methylation analysis

From: DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

Trait

CENTRAL all (N = 120)

P value

Low carb (N = 30)

Low carb + PA (N = 30)

Low fat (N = 30)

Low fat + PA (N = 30)

Gender (N; female/male)

10/110

 

4/26

0/30

5/25

1/29

Age (years)

      

 T0

49 ± 9.3

 

47 ± 7.5

50 ± 9.8

50 ± 10.2

48 ± 9.5

Weight (kg)

      

 T0

90.32 ± 11.5

 

89.98 ± 14.5

90.58 ± 11.6

87.64 ± 10.4

93.07 ± 8.5

 T18

86.66 ± 11.2

 

88.50 ± 14.2

85.44 ± 10.8

83.61 ± 9.5

89.11 ± 9.1

 Δ(T18-T0)

− 3.65 ± 5.2

< 1 × 10−11

− 1.48 ± 3.3*

− 5.14 ± 5.6***

− 4.04 ± 6.6**

− 3.96 ± 4.2***

BMI (kg/m2)

      

 T0

30.17 ± 3.3

 

30.09 ± 4.6

30.13 ± 2.4

30.38 ± 3.3

30.08 ± 2.5

 T18

28.97 ± 3.4

 

29.60 ± 4.4

28.45 ± 2.5

29.02 ± 3.4

28.80 ± 2.8

 Δ(T18-T0)

− 1.20 ± 1.7

< 1 × 10−11

− 0.49 ± 1.1*

− 1.68 ± 1.8***

− 1.36 ± 2.1**

− 1.27 ± 1.4***

Waist circumference (cm)

      

 T0

106.70 ± 8.1

 

106.56 ± 11.3

108.29 ± 6.7

104.63 ± 7.3

107.56 ± 5.9

 T18

101.98 ± 8.4

 

103.49 ± 12.0

100.96 ± 7.0

100.50 ± 6.6

102.92 ± 6.7

 Δ(T18-T0)

− 4.81 ± 5.6

< 1 × 10−14

− 3.07 ± 4.0***

− 7.3 ± 6.2***

− 3.64 ± 6.3**

− 5.29 ± 5.1***

HbA1c (%)

      

 T0

5.59 ± 0.5

 

5.66 ± 0.6

5.61 ± 0.4

5.60 ± 0.5

5.49 ± 0.4

 T18

5.51 ± 0.5

 

5.62 ± 0.8

5.47 ± 0.4

5.55 ± 0.5

5.39 ± 0.3

 Δ(T18-T0)

− 0.08 ± 0.3

0.005

− 0.04 ± 0.5

− 0.14 ± 0.2***

− 0.06 ± 0.3

− 0.10 ± 0.2**

Insulin (μU/mL)

      

 T0

18.02 ± 11.3

 

21.06 ± 15.2

16.85 ± 8.15

17.55 ± 12.1

16.56 ± 8.0

 T18

14.18 ± 7.3

 

16.66 ± 8.6

13.98 ± 8.1

12.67 ± 6.8

13.50 ± 4.7

 Δ(T18-T0)

− 3.91 ± 7.8

< 1 × 10−6

− 4.54 ± 10.5*

− 3.40 ± 6.24**

− 4.66 ± 7.8**

− 3.07 ± 6.3*

Visceral adipose tissue area (cm2)

      

 T0

176.19 ± 61.3

 

162.00 ± 63.6

196.5 ± 63.5

160.60 ± 60.8

185.70 ± 51.3

 T18

128.12 ± 49.8

 

126.41 ± 47.9

131.33 ± 56.2

121.03 ± 54.3

133.70 ± 41.0

 Δ(T18-T0)

− 48.19 ± 36.2

< 1 × 10− 27

−35.54 ± 32.7***

− 65.21 ± 38.1***

− 39.73 ± 28.4***

− 52.00 ± 38.6***

Deep subcutaneous adipose tissue area (cm2)

      

 T0

210.89 ± 70.0

 

217.50 ± 79.6

210.40 ± 64.8

201.30 ± 66.9

214.30 ± 70.2

 T18

144.71 ± 48.7

 

152.99 ± 60.2

139.50 ± 41.7

143.39 ± 41.6

142.96 ± 50.5

 Δ(T18-T0)

− 66.66 ± 42.1

< 1 × 10−33

− 64.55 ± 38.6***

− 70.95 ± 45.9***

− 59.59 ± 48.1***

− 71.31 ± 35.9***

Superficial subcutaneous adipose tissue area (cm2)

      

 T0

134.89 ± 56.5

 

146.20 ± 74.7

125.20 ± 47.6

135.90 ± 59.9

132.20 ± 37.9

 T18

106.76 ± 44.1

 

121.37 ± 55.8

94.4 ± 31.8

111.29 ± 50.3

99.99 ± 29.53

 Δ(T18-T0)

− 28.02 ± 23.9

< 1 × 10−23

− 24.85 ± 30.1***

− 30.85 ± 24.5***

− 24.01 ± 22.8***

− 32.23 ± 16.5***

  1. Metabolic traits are shown as mean ± SD values prior intervention (T0), post-intervention (T18), and the intervention specific changes (Δ(T18-T0)). P values obtained from paired t-statistics between T0 and T18 are shown for the entire cohort and indicated as: *P < 0.05; **P < 0.01; ***P < 0.001, for the intervention specific changes
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Genome Medicine

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