Fig. 3

NGP module M35 clinical and cross-omics associations and expression profile across immune cell types. a Heatmap demonstrating the associations between individual genes in module M35 and selected clinical traits. The heatmap colors denote the linear regression estimates, where all phenotypes have previously been rank normal transformed. Stars indicate statistical significance as such: ***FDR < 0.001, **FDR < 0.01, *FDR < 0.05. b Individuals within the top (red, n = 709) and bottom (blue, n = 709) tertiles of M35 expression have significantly different insulin secretion rate, triglycerides, insulin sensitivity and waist circumference. P values are shown for a two-sided t-test comparing rank normal transformed variables between the two groups. c Average expression of M35 genes across haematopoietic cell types from the BLUEPRINT consortium. d Cross-omics associations for module M35, including features from untargeted metabolomics (dark blue), targeted metabolomics (green), antibody-based proteomics (light blue) and the Myriad protein panel (red). The edge colour indicates a positive (blue) or negative (red) direction of effect for the given association. IAAT, intra-abdominal adipose tissue