Skip to main content
Fig. 6 | Genome Medicine

Fig. 6

From: Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression

Fig. 6

CircCDYL interacts with RBPs in bladder cancer and abundance is associated with overall survival. a Relative enrichment of circCDYL and CDYL host gene expression levels between immunoprecipitation (IP) and input in the bladder cancer cell line FL3. GFP was used as control. b Regulation of genes that are differentially expressed upon circCDYL KD in both J82 and UMUC3 cells. 86% of the genes show the same direction of perturbation in both cell lines. c Overlap of genes affected by circCDYL KD, and IGF2BP1 and IGF2BP2 KD, respectively, in UMUC3. P values obtained by Fisher’s exact test. d, e Gene set enrichment analysis of 50 hallmarks of cancer upon circCDYL KD (d) and IGF2BP1 KD (e) in UMUC3 cells. f Distribution of oncogenes among up- and downregulated genes upon circCDYL KD in HepG2, J82, and UMUC3 cells. g, h Expression of MYC (g) and TP53 (h) upon circCDYL KD in UMUC3. P values obtained by Wald test. i Kaplan-Meier overall survival plots for circCDYL and the host gene in patients with non-muscle invasive bladder cancer. Median expression used as cut-off; circCDYL = 0.125 RPM and CDYL = 21.4 FPKM. P values obtained by log-rank test

Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us