Fig. 2
From: Interactions between the gut microbiome and host gene regulation in cystic fibrosis
Differences between cystic fibrosis (CF) and healthy gut mucosal microbiota. a (left) Principal coordinate analysis plot based on Bray-Curtis distance indicating difference in beta-diversity between CF and healthy gut mucosal microbiome. The axes represent the percentage variance along the first two principal components and the color of samples indicates their mutation status, i.e., Healthy, CF (other), and CF (df508); (right) Boxplot depicting difference in alpha diversity (Chao1 metric) between CF and healthy gut microbiome. b Dotplot showing significantly differentially abundant OTUs (q value < 0.1), where OTUs are grouped by genera along the y-axis and colored by phylum. The x-axis indicates the log2 fold-change in CF compared to healthy as baseline. c Boxplots indicating the percentage relative abundance of taxa showing differential abundance between CF and healthy gut microbiome (q value < 0.1). d Boxplot depicting gradient-like trend in abundance for Actinobacteria for three genotypes—Healthy, CF (other), and CF (df508)