Fig. 1

Proposed general architecture of the HRIC European (inter) national databases, with varying data formats and data types referenced in a metadata repository, following formatting rules of the federated data commons as agreed at the HRIC governance level. The different users, after access control to the cloud, use the HRIC interface to access the repository, which gathers the relevant data and performs analysis, with outputs such as mathematical models, data visualizations, statistics, and patient’s profiles according to the users’ needs