Table 1 Characteristics of each cohort included in the association meta-analysis between gestational age (GA) and DNA methylation in newborns and older children
Study population | Cohort | N | N, pre-term* | N, term | Age mean (SD) | Maternal age mean (SD) | Mean GA (days) | SD GA | Min GA | Max GA | Ethnicity |
|---|---|---|---|---|---|---|---|---|---|---|---|
Newborn | ALSPAC** [29] | 249 | 10 | 239 | 0 | 29.8 (4.6) | 277 | 10.78 | 224 | 294 | European |
CBC (Hispanic) [54] | 128 | 10 | 118 | 0 | 27.3 (5.8) | 273 | 17.70 | 196 | 294 | Hispanic | |
CBC (European) [54] | 132 | 11 | 121 | 0 | 31.9 (5.7) | 273 | 16.10 | 189 | 294 | European | |
CHS [55] | 120 | 7 | 113 | 0 | 29.4 (5.6) | 277 | 11.20 | 230 | 294 | Mixed | |
CHAMACOS [56] | 110 | 11 | 99 | 0 | 25.3 (5.0) | 272 | 10.66 | 210 | 294 | Hispanic | |
EDEN [57] | 100 | 2 | 98 | 0 | 30.8 (5.0) | 276 | 10.11 | 217 | 287 | European | |
EXPOSOMICS (Environage + PiccoliPlus + RHEA) [58] | 252 | 17 | 235 | 0 | 30.5 (4.8) | 273 | 10.50 | 217 | 294 | European | |
Generation R [59] | 486 | 22 | 464 | 0 | 31.9 (4.2) | 280 | 9.00 | 239 | 294 | European | |
INMA [60] | 134 | 2 | 132 | 0 | 30.5 (4.1) | 278 | 9.57 | 234 | 286 | European | |
IOW F2 [61] | 93 | 2 | 91 | 0 | 23.2 (2.6) | 278 | 10.95 | 236 | 294 | European | |
MoBa1** [30] | 749 | 18 | 731 | 0 | 29.9 (4.3) | 279 | 10.36 | 209 | 294 | European | |
MoBa2** [30] | 460 | 15 | 445 | 0 | 30.0 (4.5) | 278 | 10.49 | 209 | 294 | European | |
MoBa3 [20] | 177 | 3 | 174 | 0 | 29.6 (4.4) | 279 | 10.38 | 199 | 294 | European | |
PREDO [62] | 308 | 5 | 303 | 0 | 33.4 (5.7) | 278 | 11.20 | 186 | 294 | European | |
Project Viva [63] | 150 | 3 | 147 | 0 | 33.2 (4.5) | 278 | 10.11 | 216 | 294 | European | |
Meta-analysis | 3648 | 138 | Â | Â | Â | Â | Â | Â | Â | Â | |
Early childhood | BAMSE [64] | 145 | 10 | 135 | 4.3 (0.2) | 31.2 (4.4) | 275 | 16.22 | 187 | 293 | European |
EDEN [64] | 89 | 2 | 87 | 5.6 (0.1) | 30.8 (5.1) | 276 | 9.23 | 245 | 287 | European | |
INMA [64] | 71 | 1 | 70 | 4.4 (0.2) | 30.6 (4.3) | 279 | 8.70 | 249 | 288 | European | |
PIAMA [64] | 148 | 4 | 144 | 4.1 (0.2) | 30.6 (3.6) | 278 | 10.51 | 233 | 294 | European | |
Meta-analysis | 453 | 17 | Â | Â | Â | Â | Â | Â | Â | Â | |
School age | ALSPAC [29] | 273 | 12 | 261 | 7.5 (0.1) | 29.9 (4.6) | 277 | 10.99 | 224 | 294 | European |
BAMSE [64] | 141 | 10 | 131 | 8.4 (0.4) | 31.4 (4.5) | 276 | 15.96 | 197 | 293 | European | |
BAMSE_EpiGene [64] | 232 | 8 | 224 | 8.3 (0.5) | 30.8 (4.4) | 278 | 11.47 | 209 | 294 | European | |
PIAMA [64] | 134 | 3 | 131 | 8.1 (0.3) | 30.5 (3.6) | 278 | 10.61 | 233 | 294 | European | |
Project Viva [63] | 119 | 2 | 117 | 7.8 (0.7) | 33.5 (4.4) | 278 | 10.32 | 216 | 294 | European | |
Meta-analysis | 899 | 35 | Â | Â | Â | Â | Â | Â | Â | Â | |
Adolescence | ALSPAC [29] | 272 | 13 | 259 | 17.2 (1.0) | 29.9 (4.6) | 277 | 11.04 | 224 | 294 | European |
BAMSE [64] | 159 | 7 | 152 | 16.7 (0.4) | 31.2 (4.4) | 278 | 12.70 | 187 | 294 | European | |
IOW F1 [61] | 97 | 2 | 95 | 17.1 (0.5) | 27.1 (5.1) | 280 | 9.83 | 238 | 294 | European | |
NFBC86 [65] | 287 | 9 | 276 | 16.1 (0.4) | 29.0 (5.1) | 280 | 8.65 | 237 | 294 | European | |
RAINE [66] | 314 | 9 | 305 | 17.0 (0.3) | 29.0 (5.8) | 274 | 11.90 | 196 | 294 | European | |
Meta-analysis | 1129 | 40 | Â | Â | Â | Â | Â | Â | Â | Â |