Table 3 The top 10 Bonferroni-significant CpGs ranked by the magnitude of positive and negative effect (5 CpGs each) from the meta-analysis on the association between continuous GA and offspring DNA methylation at birth adjusted for estimated cell proportions
CpGID | Chr | Genomic coordinates | Gene (Illumina annotation) | Relation to island | Distance to nearest gene | UCSC known gene | Coefficient* | P value | Direction of effect in each cohort** |
|---|---|---|---|---|---|---|---|---|---|
cg13036381 | 3 | 1.6E+ 08 | LOC401097 | N_Shore | − 927 | C3orf80 | 0.00278 | 1.01E−47 | +++++ − +++++++++ |
cg18183624 | 17 | 47,076,904 | IGF2BP1 | S_Shore | 0 | IGF2BP1 | 0.00277 | 8.36E−80 | +++++++++++++++ |
cg04213841 | 13 | 49,792,685 | NA | N_Shore | − 1788 | MLNR | 0.00245 | 3.60E−43 | +++++?+++++++++ |
cg07738730 | 17 | 47,077,165 | IGF2BP1 | S_Shore | 0 | IGF2BP1 | 0.00217 | 2.87E−65 | +++++++++++++ − + |
cg09476997 | 16 | 2,087,932 | SLC9A3R2 | N_Shore | 0 | SLC9A3R2 | 0.00208 | 2.41E−49 | +++++++++++++++ |
cg04347477 | 12 | 1.25E+ 08 | NCOR2 | Island | 833 | NCOR2 | −0.00361 | 3.38E−32 | --------------- |
cg08943494 | 11 | 36,422,615 | PRR5L | OpenSea | 69 | PRR5L | −0.00360 | 1.95E−24 | --------------- |
cg20334115 | 1 | 2.26E+ 08 | PYCR2 | N_Shelf | 0 | PYCR2 | −0.00350 | 1.40E−35 | --------------- |
cg16725984 | 16 | 89,735,184 | C16orf55 | Island | 0 | C16orf55 | −0.00325 | 3.70E−26 | --------------- |
cg16103712 | 8 | 99,023,869 | MATN2 | OpenSea | 7355 | MATN2 | −0.00304 | 2.70E−129 | --------------- |