Fig. 2
From: Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer
Exclusion of FLT3 as a driver gene. a Box plot showing no significant correlation between FLT3 gene copy number and FLT3 mRNA expression (log10 (normalized RSEM value + 1)) in the TCGA cohort. Control/matched normal tissue, n = 51; Balanced, n = 196; Gain, n = 129; Amplification, n = 46. b The scatter plot illustrates no correlation in FLT3 copy number and FLT3 mRNA expression (log2 (TPM + 1)) in 58 CRC cell lines (R = − 0.41, p = 0.0016; Pearson). The red line represents the noise threshold (TPM = 1). c Colony formation assay showing significant overexpression of FLT3 in OXCO-2 cells (p = 0.03433; t test) but no significant changes in proliferation (p = 0.1866; t test)