Table 2 Toxicity profile
Grades 1–2 | Grade 3 | Grade 4 | Grade 5 | |
|---|---|---|---|---|
Non-hematological adverse events | ||||
Fatigue | 15 (24.2%) | 0 | 0 | 0 |
Neuropathy | 23 (37.1%) | 0 | 0 | 0 |
Anorexia | 22 (35.5%) | 0 | 0 | 0 |
Alopecia | 41 (66.1%) | 0 | 0 | 0 |
Diarrhea | 6 (9.7%) | 0 | 0 | 0 |
Epistaxis | 5 (8.1%) | 0 | 0 | 0 |
Vomiting | 5 (8.1%) | 1 (1.6%) | 0 | 0 |
Peripheral edema | 6 (9.7%) | 1 (1.6%) | 0 | 0 |
Hypertension | 8 (12.9%) | 5 (8.1%) | 0 | 0 |
Constipation | 5 (8.1%) | 0 | 0 | 0 |
Dyspnea | 7 (11.3%) | 0 | 0 | 0 |
Weight decreased | 5 (8.1%) | 0 | 0 | 0 |
Ascites | 3 (4.8%) | 0 | 0 | 0 |
Myalgia | 6 (9.7%) | 0 | 0 | 0 |
Nausea | 9 (14.5%) | 0 | 0 | 0 |
Rash | 8 (12.9%) | 1 (1.6%) | 0 | 0 |
Mucositis | 11 (17.7%) | 0 | 0 | 0 |
Back pain | 4 (6.5%) | 0 | 0 | 0 |
Cough | 4 (6.5%) | 0 | 0 | 0 |
Hematologic adverse events | ||||
Neuropenia | 13 (21.0%) | 16 (25.8%) | 5 (8.1%) | 0 |
Febrile neutropenia | 0 | 1 (1.6%) | 0 | 0 |
Anemia | 18 (29.0%) | 2 (3.2%) | 0 | 0 |
Thrombocytopenia | 2 (3.2%) | 0 | 0 | 0 |