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Table 1 Cohort data for IHD, MI, and early MI, and European UK Biobank Population

From: Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later

 

Ischemic heart disease (IHD) (8.96% prevalence, 39,516 total cases)

Myocardial infarction (MI) (3.61% prevalence, 15,930 total cases)

Early MI (0.15% prevalence, 669 total cases)

UK Biobank European Subset (441,101 individuals)

Sex

33% female (12,890)

67% male (26,626)

23% female (3599)

77% male (12,331)

14% female (96)

86% male (576)

54% female (238,358)

46% male (202,743)

Smoking status

13% current (5199)

47% past (18,387)

40% never (15,930)

16% current (2564)

49% past (7774)

35% never (5592)

28% current (191)

43% past (285)

29% never (193)

10% current (44,710)

35% past (155,055)

55% never (241,336)

Diabetes type 2

19% (7480)

20% (3214)

26% (177)

5% (23,634)

Family history heart disease

45% (17,970)

48% (7599)

58% (386)

24% (103,639)

Mean systolic blood pressure

143.5 ± 20.08 mmHg

142.1 ± 20.5 mmHg

133.7 ± 18.6 mmHg

140.1 ± 19.6 mmHg

Mean BMI

29.1 ± 5.0 kg/m2

29.0 ± 4.8 kg/m2

30.3 ± 5.5 kg/m2

27.4 ± 4.8 kg/m2

Mean birth year

1947 ± 6 years

1947 ± 6 years

1957 ± 6 years

1951 ± 8 years

Mean Cholesterol

5.2 ± 1.3 mM/L

5.0 ± 1.3 mM/L

4.7 ± 1.2 mM/L

5.7 ± 1.1 mM/L

Mean triglycerides

2.0 ± 1.1 mM/L

2.0 ± 1.1 mM/L

2.2 ± 1.3 mM/L

1.8 ± 1.0 mM/L

Mean LDL

3.2 ± 0.9 mM/L

3.1 ± 0.9 mM/L

2.9 ± 0.9 mM/L

3.6 ± 0.9 mM/L

  1. All data displayed in this table is for individuals of the European-only subset in the UK Biobank. Entries in brackets indicate number of cases or individuals