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Table 2 Percentile vs. prevalence statistics for multivariate logistic regression

From: Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later

  Percentile PRS only (4-feature model) Established-at-birth only (5-feature model) Established-at-birth plus PRS (9-feature model) Established-at-birth plus non-fixed (14-feature model) Established-at-birth plus non-fixed plus PRS (18-feature model)
IHD Top percentile 21.95% ± 1.39 13.52% ± 1.10 29.98% ± 1.65 55.71% ± 1.83 60.25% ± 1.37
IHD Middle percentile 8.76% ± 0.80 5.48% ± 0.63 7.69% ± 0.89 5.34% ± 0.70 4.50% ± 0.69
IHD Lowest percentile 3.45% ± 0.47 4.56% ± 0.71 2.79% ± 0.63 0.48% ± 0.18 0.41% ± 0.12
MI Top percentile 11.38% ± 1.05 6.60% ± 0.72 16.78% ± 1.10 30.95% ± 1.63 35.90% ± 1.66
MI Middle percentile 3.19% ± 0.35 1.72% ± 0.30 1.95% ± 0.42 1.54% ± 0.46 1.11% ± 0.20
MI Lowest percentile 0.68% ± 0.31 1.98% ± 0.34 0.59% ± 0.22 0.09% ± 0.09 0.14% ± 0.14
Early MI Top percentile 0.88% ± 0.32 0.27% ± 0.28 1.34% ± 0.42 4.15% ± 0.52 4.67% ± 0.83
Early MI Middle percentile 0.07% ± 0.08 0.02% ± 0.05 0.07% ± 0.11 0.02% ± 0.05% 0.00% ± 0.05
Early MI Lowest percentile 0.00% ± 0.00 0.02% ± 0.05 0.00% ± 0.00 0.00% ± 0.00 0.00% ± 0.00
  1. Entries are observed prevalence of IHD, MI, or early MI, plus or minus 95% CI from 10-fold cross-validation in each indicated model for the top, middle, and bottom 1% of polygenic risk