| |
Percentile
|
PRS only (4-feature model)
|
Established-at-birth only (5-feature model)
|
Established-at-birth plus PRS (9-feature model)
|
Established-at-birth plus non-fixed (14-feature model)
|
Established-at-birth plus non-fixed plus PRS (18-feature model)
|
|---|
|
IHD
|
Top percentile
|
21.95% ± 1.39
|
13.52% ± 1.10
|
29.98% ± 1.65
|
55.71% ± 1.83
|
60.25% ± 1.37
|
|
IHD
|
Middle percentile
|
8.76% ± 0.80
|
5.48% ± 0.63
|
7.69% ± 0.89
|
5.34% ± 0.70
|
4.50% ± 0.69
|
|
IHD
|
Lowest percentile
|
3.45% ± 0.47
|
4.56% ± 0.71
|
2.79% ± 0.63
|
0.48% ± 0.18
|
0.41% ± 0.12
|
|
MI
|
Top percentile
|
11.38% ± 1.05
|
6.60% ± 0.72
|
16.78% ± 1.10
|
30.95% ± 1.63
|
35.90% ± 1.66
|
|
MI
|
Middle percentile
|
3.19% ± 0.35
|
1.72% ± 0.30
|
1.95% ± 0.42
|
1.54% ± 0.46
|
1.11% ± 0.20
|
|
MI
|
Lowest percentile
|
0.68% ± 0.31
|
1.98% ± 0.34
|
0.59% ± 0.22
|
0.09% ± 0.09
|
0.14% ± 0.14
|
|
Early MI
|
Top percentile
|
0.88% ± 0.32
|
0.27% ± 0.28
|
1.34% ± 0.42
|
4.15% ± 0.52
|
4.67% ± 0.83
|
|
Early MI
|
Middle percentile
|
0.07% ± 0.08
|
0.02% ± 0.05
|
0.07% ± 0.11
|
0.02% ± 0.05%
|
0.00% ± 0.05
|
|
Early MI
|
Lowest percentile
|
0.00% ± 0.00
|
0.02% ± 0.05
|
0.00% ± 0.00
|
0.00% ± 0.00
|
0.00% ± 0.00
|
- Entries are observed prevalence of IHD, MI, or early MI, plus or minus 95% CI from 10-fold cross-validation in each indicated model for the top, middle, and bottom 1% of polygenic risk
