Fig. 6
From: Pan-cancer detection of driver genes at the single-patient resolution
Validation of sysSVM2 in osteosarcoma. a Distribution of osteosarcoma canonical drivers across the PCAWG osteosarcoma cohort. Lists of canonical drivers for osteosarcoma derived from the literature [36, 37] and mapped to samples where they were damaged. Numbers of samples are indicated above each bar. b Recurrence of the 129 sysSVM2 predictions across the PCAWG osteosarcoma cohort. The percentages of genes that are predicted in 1, 2 and ≥ 3 are shown. c Patient-level predictions of osteosarcoma canonical drivers by sysSVM2 when considering the top five genes. The number of samples in which each canonical driver is damaged (yellow) and predicted as a driver by sysSVM2 (pink) is shown. d Gene set enrichment analysis of 81 sysSVM2 predictions with no previously reported involvement in cancer. Reactome level 2 and above were considered and pathways with FDR < 0.1 are shown