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Table 2 Association between polygenic risk scores and longitudinal changes in lipid levels over 3 years in adolescents (n = 620)

From: Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians

Polygenic risk score Lipid trait Lipid traits at baseline (n = 620) Lipid traits at follow-up (n = 620) Three-year changes in lipid traits (n = 620)
β SE Pa β SE Pb β SE Pc
PRSTC Total cholesterol 0.0507 0.0066 6.3 × 10−14 0.0480 0.0064 2.7 × 10−13 0.0151 0.0050 2.8 × 10−3
PRSTG Triglycerides 0.1076 0.0146 5.9 × 10−13 0.0843 0.0153 5.5 × 10−8 0.0361 0.0145 0.0130
PRSHDL HDL cholesterol 0.0496 0.0068 9.6 × 10−13 0.0615 0.0071 6.7 × 10−17 0.0285 0.0058 1.4 × 10−6
PRSLDL LDL cholesterol 0.0863 0.0104 7.5 × 10−16 0.0849 0.0106 4.7 × 10−15 0.0236 0.0080 3.1 × 10− 3
  1. Lipid traits at baseline and follow-up were natural log (ln) transformed. The 3-year changes in lipid traits were transformed as ln(Y + 1). a P values were obtained from linear regression with the adjustment for principal components, sex, age at baseline, and BMI at baseline. b P values were obtained from linear regression with the adjustment for principal components, sex, age at follow-up, and BMI at baseline and follow-up. c P values were obtained from linear regression with the adjustment for principal components, sex, age at follow-up, BMI at baseline and follow-up, and lipid trait at baseline