Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians

Table 2 Association between polygenic risk scores and longitudinal changes in lipid levels over 3 years in adolescents (n = 620)

Polygenic risk score	Lipid trait	Lipid traits at baseline (n = 620)			Lipid traits at follow-up (n = 620)			Three-year changes in lipid traits (n = 620)
Polygenic risk score	Lipid trait	β	SE	P^a	β	SE	P^b	β	SE	P^c
PRS_TC	Total cholesterol	0.0507	0.0066	6.3 × 10⁻¹⁴	0.0480	0.0064	2.7 × 10⁻¹³	0.0151	0.0050	2.8 × 10⁻³
PRS_TG	Triglycerides	0.1076	0.0146	5.9 × 10⁻¹³	0.0843	0.0153	5.5 × 10⁻⁸	0.0361	0.0145	0.0130
PRS_HDL	HDL cholesterol	0.0496	0.0068	9.6 × 10⁻¹³	0.0615	0.0071	6.7 × 10⁻¹⁷	0.0285	0.0058	1.4 × 10⁻⁶
PRS_LDL	LDL cholesterol	0.0863	0.0104	7.5 × 10⁻¹⁶	0.0849	0.0106	4.7 × 10⁻¹⁵	0.0236	0.0080	3.1 × 10^− 3

Lipid traits at baseline and follow-up were natural log (ln) transformed. The 3-year changes in lipid traits were transformed as ln(Y + 1). ^a P values were obtained from linear regression with the adjustment for principal components, sex, age at baseline, and BMI at baseline. ^b P values were obtained from linear regression with the adjustment for principal components, sex, age at follow-up, and BMI at baseline and follow-up. ^c P values were obtained from linear regression with the adjustment for principal components, sex, age at follow-up, BMI at baseline and follow-up, and lipid trait at baseline

ISSN: 1756-994X