Table 4 Odds ratios (OR) for the association between per standard deviation decrease in gSOS and increased odds of incident fracture
From: Improved prediction of fracture risk leveraging a genome-wide polygenic risk score
|  | OR (95% CI)* | p value | OR (95% CI), adjusted for RFs§ | p value, adjusted for RFs |
|---|---|---|---|---|
UK Biobank test dataset (N = 80,014) | ||||
 Major osteoporotic fracture | 1.46 (1.38–1.55) | 1.1 × 10−37 | 1.42 (1.34–1.51) | 1.4 × 10−32 |
 Hip fracture | 1.37 (1.19–1.57) | 6.3 × 10−6 | 1.34 (1.16–1.53) | 3.7 × 10−5 |
MrOS US (N = 4663) | ||||
 Major osteoporotic fracture | 1.38 (1.26–1.51) | 2.2 × 10−12 | 1.31 (1.17–1.45) | 1.1 × 10−6 |
 Hip fracture | 1.37 (1.21–1.56) | 5.5 × 10−7 | 1.33 (1.15–1.55) | 1.4 × 10−4 |
MrOS Sweden (N = 1880) | ||||
 Major osteoporotic fracture | 1.45 (1.28–1.65) | 5.3 × 10−9 | 1.38 (1.17–1.63) | 1.3 × 10−4 |
 Hip fracture | 1.31 (1.08–1.58) | 5.0 × 10−3 | 1.35 (1.05–1.72) | 1.8 × 10−2 |
SOF (N = 3615) | ||||
 Major osteoporotic fracture | 1.35 (1.24–1.47) | 1.0 × 10−11 | 1.34 (1.21–1.48) | 7.3 × 10−9 |
 Hip fracture | 1.31 (1.19–1.43) | 1.4 × 10−8 | 1.32 (1.19–1.47) | 4.1 × 10−7 |
CKB (N = 25,034) | ||||
 Major osteoporotic fracture | 1.26 (1.13–1.41) | 5.3 × 10−5 | 1.22 (1.09–1.36) | 6.8 × 10−4 |
 Hip fracture | 1.25 (0.98–1.60) | 7.1 × 10−2 | 1.21 (0.94–1.54) | 0.14 |